Principal Investigator
Dr. Samarendra K Singh
Professional Experience:
Assistant Professor, School of Biotechnology, BHU
Research Associate University of Virginia (2014-2017),
Post Doc./Staff Scientist NIH (2010-2014)
Post Doc. Medical University of South Carolina (2007-2010)
Ph.D., IICB Kolkata, 2007
Email: samarendra.singh@bhu.ac.in
Team Members
Garima Singh, Ph.D.
PhD on "Role of miRNAs in Cell Cycle Regulation in Cervical Cancer Cells."
Email: garima.singh10@bhu.ac.in
Gajender Singh (Ph.D. Scholar)
Cryo-EM Study of Essential Mammalian Protein: Transcription Termination Factor 1 (TTF1) and its Role in Cancer Etiology
Email: gajender97@bhu.ac.in
Sonika Kumari Sharma (Ph.D. Scholar)
Neelu Mishra (Ph.D. Scholar)
Aastha Soni (UGC- JRF)
Towards Developing Diagnostics Markers and Understanding Resistance in Cervical Cancer Patients
Email: aasthaasonii19@gmail.com
Alumni
Kumud Tiwari, Ph.D.
PhD on "Structural and Functional Studies of an Essential Mammalian Protein: Transcription Termination Factor 1 (TTF1)"
Email: kumud.tiwari10@bhu.ac.in
Post Doctoral fellow at USCD Kumud Tiwari | UCSD Profiles
Smrutimayee Prusty
" My PI was Dr. Samarendra Singh from Cell cycle and Cancer Lab, Department of Biotechnology, Banaras Hindu University, Varanasi. I had a great time during my first summer internship. The people in the lab were super friendly and made me feel right at home. "
link: https://ngsf.in/smrutimayee-prusty/
Snehendu Bose, BARC Scientist
"Before coming to your lab, I had absolutely zero idea about research environment. Eight months of rigorous work experience in your lab prepared my base and my thought process immensely.
Thank you, sir, for everything always."
M.Sc. Dissertees
Sabuj Samaddar
Anshika Singh
Anshika Singh
Batch (2023-25)
Anshika Singh
Anshika Singh
Anshika Singh
Batch (2023-25)
Deepanshu
Anshika Singh
Deepanshu
Batch (2023-25)
Kunal Yadav
Anshika Singh
Deepanshu
Batch (2023-25)
Akshay Vijay Rathod
Akshay Vijay Rathod
Akshay Vijay Rathod
Batch (2022-24)
Manshi Kumari
Akshay Vijay Rathod
Akshay Vijay Rathod
Batch (2022-24)
Prashant Prakash
Akshay Vijay Rathod
Prashant Prakash
Batch (2022-24)
Simran Mathur
Akshay Vijay Rathod
Prashant Prakash
Batch (2022-24)
Aastha Dorata
Saloni Khatri
Saloni Khatri
Batch (2021-23)
Saloni Khatri
Saloni Khatri
Saloni Khatri
Batch (2021-23)
Snehendu Bose
Saloni Khatri
Snehendu Bose
Batch (2021-23)
Interdisciplinary Collaborations and Projects
Evaluation of Clinical Relevance of ccfDNA in Cervical Cancer (2018-2020)
Evaluation of Clinical Relevance of ccfDNA in Cervical Cancer (2018-2020)
Evaluation of Clinical Relevance of ccfDNA in Cervical Cancer (2018-2020)
We in collaboration with Dr. Lalit Agrawal (IMS, BHU) and his student Dr. Anju Srivastava discovered that in cervical cancer patients ccfDNA load increases as the cancer burden increases. Also, this ccfDNA load drastically decreases during chemo/radiation therapy. Hence, ccfDNA can be used to develop an efficient marker to detect chemoresistance in patients undergoing treatment and detection of cancer burden for CC patients.
SCN1A SNPs and its implication in idiopathic Epilepsy (2022-2023)
Evaluation of Clinical Relevance of ccfDNA in Cervical Cancer (2018-2020)
Evaluation of Clinical Relevance of ccfDNA in Cervical Cancer (2018-2020)
We along with our collaborator Dr. Deepika Joshi and her student Aparna Khatri had discovered novel SNPs in SCN1A gene associated with Juvenile Myoclonic epilepsy which further need to be explored. We also have found a known mutation which is predominant in North Indian patient population and is related with higher GFAP serum level.
Identifying microRNA signatures in Urinary Bladder Cancer (2023- Present)
Evaluation of Clinical Relevance of ccfDNA in Cervical Cancer (2018-2020)
Towards developing diagnostics marker in Cervical Cancer patients (2022- Present)
Our collaboration with Dr. Lalit from Department of Urology, IMS, BHU is about finding out microRNA signatures in the urinary bladder cancer patients. Our student Dr. Anil Kumar (M.Ch., Urology) detects the miRNA pattern in urine/ tissue sample to develop a potential theragnostic marker.
Towards developing diagnostics marker in Cervical Cancer patients (2022- Present)
Estimation of plasma level of miR126-3p in Type II Diabetes Mellitus patients (2024- Present)
Towards developing diagnostics marker in Cervical Cancer patients (2022- Present)
One of our objectives of collaboratory project with Prof. Sunil Choudhary (Radiologist, IMS, BHU) and Dr. Vimal Kishore (IoS, BHU) is to find out the source of ccfDNA in cervical cancer patients to develop a highly sensitive novel diagnostics marker. We are also trying to understand the radio-resistance in the CC patients.
Exploring novel microRNA signatures in Gallbladder Cancer patients (2024-Present)
Estimation of plasma level of miR126-3p in Type II Diabetes Mellitus patients (2024- Present)
Estimation of plasma level of miR126-3p in Type II Diabetes Mellitus patients (2024- Present)
In collaboration with Prof. Puneet (Surgery, IMS, BHU) our MD Student Dr. Saravana Bhaskar, is trying to identify the novel microRNA signatures in gallbladder patients which could be further used to develop potential therapeutics.
Estimation of plasma level of miR126-3p in Type II Diabetes Mellitus patients (2024- Present)
Estimation of plasma level of miR126-3p in Type II Diabetes Mellitus patients (2024- Present)
Estimation of plasma level of miR126-3p in Type II Diabetes Mellitus patients (2024- Present)
In collaboration with Prof. Dhiraj Kishore (Medicine, IMS, BHU) and his MD Student Dr. Aman Singh, we are trying to evaluate the level of circulating miR-126-3p in plasma of Type 2 DM patients to develop a minimally invasive diagnostic markers for Type 2 DM.